Present investigation has recorded ehrlichiosis associated C-reactive protein status in dogs. Total 79 dogs were screened for ehrlichiosis based on the clinical diagnosis criteria. All the screened dogs underwent for blood smear examination followed by primary and nested PCR analysis which confirm total 64 dog positive for ehrlichiosis. These confirmed cases were taken for further analysis to assess the extent of inflammation caused by acute phase protein such as C-reactive protein. Results of present investigation revealed significant increase in serum concentration of canine C-reactive protein in ehrlichiosis affected dogs as compared to healthy ones. Conventional treatment of diseased animals reduces these values towards the reference values as assessed in healthy animals. It can be concluded thatserum level of C-reactive protein is significantly increases in case of canine monocytic ehrlichiosis and can be used as potent clinical biomarker for assessment of extra cytokines induced inflammatory reaction.