Diseases of the intestines are many a times hidden challenges. One such challenge is Chronic inflammatory enteropathy (CIE) is characterised by the presence of persistent or recurrent gastrointestinal signs includes diarrhoea, vomiting and weight loss for more than three weeks. CIE dogs were categorised into food responsive enteropathy (FRE), antibiotic responsive enteropathy(ARE), steroid  responsive enteropathy (SRE) and non- responsive enteropathy (NRE) based on the response to elimination trail, antibiotic treatment and immunosuppressive therapy. The study was conducted to document the canine chronic inflammatory enteropathy index, endoscopic and histopathologic changes CIE dogs. 40 dogs with chronic GI signs were selected for this study and subjected for detailed physical examination, haematology, serum biochemistry, radiography and ultrasonographic examination CIE was diagnosed in 13 dogs based on the endoscopic and histopathologic changes. Moderate form of CCECAI score was recorded highly in this study. Haematological findings of CIE dogs include leucocytosis with neutrophilia and monocytosis and no significant difference were noticed in the biochemical parameters of CIE. Increased friability and hyperaemia was the predominant endoscopic changes of CIE dogs. In all the dogs with CIE of various categories showed lymphoplasmacytic infiltration on histopathology.