The study conducted at the Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, during the Rabi season of 2022-2023, focuses on assessing the economic feasibility and sustainable productivity of seedling bio-priming coupled with reduced inorganic fertilizer doses for high-value vegetable crops. Utilizing Trichoderma harzianum (TH) and Bacillus subtilis (BS) in seedling bio-priming, the experiment examined three crops under varied mineral fertilizer conditions. Results indicate that employing microbial consortia in high-value vegetable cultivation is economically viable for smallholder farmers, with a high cost-benefit ratio. The combination of T. harzianum + B. subtilis along with 75% recommended dose of NPK fertilizer emerged as the most effective treatment for enhancing productivity. In conclusion, incorporating efficient microbes will reduce the dependence on chemical fertilizers, promoting sustainable production, and ensuring the technical and economic viability of high-value vegetable cultivation for smallholder farmers.