One of the major achievements in medicine was in 1928 when the first antibiotic penicillin was discovered by Alexander Flemming. They were touted as ‘Miracle drug’ and brought great promise of a future without infectious disease. And now we face the threat of superbugs or nightmare bacteria threatening to render our future bleak. Each year, Anti Micorbial Resistance (AMR) kills more than 700,000 people globally. A ‘superbug’ is a bacterium capable of causing uncontrollable infections, a microbe which can’t be eradicated, and a germ which can kill when normally it shouldn’t. These are no less than “nightmare bacteria” that have a potential to threaten people in every nook and corner of the world catastrophically. Widespread use of antibiotics without good stewardship has eventually led to emergence of multiple drug resistance against almost all of our life saving antimicrobial drugs including the last resort wonder drug colistin. Thus, if we still do not face this problem head on and make some strict decisions, we may be looking at a post antibiotic era marked with minor wounds becoming life threatening and people dying from simple infections.