Original Article

Hematological and Serum Biochemical Evaluation of Doxorubicin Induced Toxicity in Wistar Male Rats and its Amelioration with Hesperidin

Year: 2024 | Month: April | Volume 14 | Issue 2

References (35)

1.Aboraya, D.M., El Baz, A., Risha, E.F. and Abdelhamid, F.M. 2022. Hesperidin ameliorates cisplatin induced hepatotoxicity and attenuates oxidative damage, cell apoptosis, and inflammation in rats. Saudi J. Biol. Sci., 29(5): 3157-3166.

View at Google Scholar

2.Adamcova, M., Skarkova, V., Seifertova, J. and Rudolf, E. 2019. Cardiac troponins are among targets of doxorubicin-induced cardiotoxicity in hiPCS-CMs. Int. J. Mol. Sci., 20(11): 2638.

View at Google Scholar

3.Akter, H., Rashid, M.M., Islam, M.S., Hossen, M.A., Rahman, M.A., Algheshairy, R.M. and Alnajeebi, A.M. 2022. Biometabolites of Tamarindus indica play a remarkable cardioprotective role as a functional food in doxorubicininduced cardiotoxicity models. J. Funct. Foods, 96: 105212.

View at Google Scholar

4.Ansar, S., Abudawood, M., Alaraj, A.S. and Hamed, S.S. 2018. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol. Toxicol., 19: 1-6.

View at Google Scholar

5.Asensio-López, M.C., Soler, F., Pascual-Figal, D., Fernández- Belda, F. and Lax, A. 2017. Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes. PloS One, 12(2): e0172803.

View at Google Scholar

6.Badmus, J.A., Rafiu, M.A. and Fatoki, J.O. 2022. The protective effect of ethanol leaf extract of Annona muricata against doxorubicin toxicity via modulations of hematological, serum biochemical, antioxidant enzymes, and lipid peroxidation. Phytomed. Plus, 2(3): 100328.

View at Google Scholar

7.Bashandy, M.A., Zawahry, E.I.E., Bashandy, S.A. and Abdel Naby, M.F. 2017. The protective role of β-Carotene and Hesperidin on some hematological and myocardial measurements against imidacloprid toxicity in albino rats. J. Pharm. Pharmacol., 5: 798-806.

View at Google Scholar

8.Birari, L., Wagh, S., Patil, K.R., Mahajan, U.B., Unger, B., Belemkar, S. and Patil, C.R. 2020. Aloin alleviates doxorubicin-induced cardiotoxicity in rats by abrogating oxidative stress and pro-inflammatory cytokines. Cancer Chemother. Pharmacol., 86: 419-426.

View at Google Scholar

9.Caglayan, C., Kandemir, F.M., Darendelio?lu, E., Küçükler, S. and Ayna, A. 2021. Hesperidin protects liver and kidney against sodium fluoride-induced toxicity through antiapoptotic and anti-autophagic mechanisms. Life Sci., 281: 119730.

View at Google Scholar

10.Chen, M., Gu, H., Ye, Y., Lin, B., Sun, L., Deng, W. and Liu, J. 2010. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem. Toxicol., 48(10): 2980-2987.

View at Google Scholar

11.Choi, S.S., Lee, S.H. and Lee, K.A. 2022. A comparative study of hesperetin, hesperidin and hesperidin glucoside: Antioxidant, anti-inflammatory, and antibacterial activities in vitro. Antioxidants, 11(8): 1618.

View at Google Scholar

12.Farag, M.R., Moselhy, A.A., El-Mleeh, A., Aljuaydi, S.H., Ismail, T.A., Di-Cerbo, A. and Abou-Zeid, S.M. 2021. Quercetin alleviates the immunotoxic impact mediated by oxidative stress and inflammation induced by doxorubicin exposure in rats. Antioxidants, 10(12): 1906.

View at Google Scholar

13.Hozayen, W.G., Abou-Seif, H.S. and Amin, S. 2014. Protective effects of ruitn and/or hesperidin against doxorubicin-induced hepatotoxicity. Int. J. Clin. Nutr.2(1): 11-7.

View at Google Scholar

14.Hussein, M. and Othman, S. 2011. Structure activity relationship of antioxidative property of hesperidin. Int. J. Pharmaceut. Res. Develop., 3(8): 19-29.

View at Google Scholar

15.Kumral, A., Soluk-Tekke?in, M., Olgaç, V., Do?ru-Abbaso?lu, S., Türko?lu, Ü. and Uysal, M. 2016. Beneficial effects of carnosine and carnosine plus vitamin E treatments on doxorubicin-induced oxidative stress and cardiac, hepatic, and renal toxicity in rats. Hum. Exp. Toxicol., 35(6): 635-643.

View at Google Scholar

16.Kuzu, M., Kandemir, F.M., Y?ld?r?m, S., Ça?layan, C. and Küçükler, S. 2021. Attenuation of sodium arsenite-induced cardiotoxicity and neurotoxicity with the antioxidant, antiinflammatory, and antiapoptotic effects of hesperidin. Environ. Sci. Pollut. Res. Int.,28: 10818-10831.

View at Google Scholar

17.Liu, P., Li, J., Liu, M., Zhang, M., Xue, Y., Zhang, Y. and Chu, L. 2021. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.Biomed. Pharmacother, 139: 111552.

View at Google Scholar

18.Liu, P., Wu, J., Yu, X., Guo, L., Zhao, L., Ban, T. and Huang, Y. 2023. Metabolomics and Network Analyses Reveal Phenylalanine and Tyrosine as Signatures of Anthracycline- Induced Hepatotoxicity. Pharmaceuticals, 16(6): 797.

View at Google Scholar

19.Marina, N.M., Cochrane, D., Harney, E., Zomorodi, K., Blaney, S., Winick, N. and Link, M.P. 2002. Dose escalation and pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in children with solid tumors: a pediatric oncology group study.Clin Cancer Res., 8(2): 413-418.

View at Google Scholar

20.Mohamed, E.T. and Safwat, G.M. 2016. Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil. Beni Suef Univ. J. Basic Appl. Sci., 5(2): 208-215.

View at Google Scholar

21.Mohan, M., Kamble, S., Gadhi, P. and Kasture, S. 2010. Protective effect of Solanum torvum on doxorubicin-induced nephrotoxicity in rats. Food Chem. Toxicol., 48(1): 436-440.

View at Google Scholar

22.Molehin, O.R., Adeyanju, A.A., Adefegha, S.A. and Akomolafe, S.F. 2018. Protocatechuic acid mitigates adriamycin-induced reproductive toxicities and hepatocellular damage in rats. Comp. Clin. Path., 27: 1681-1689.

View at Google Scholar

23.Nebigil, C.G. and Desaubry, L. 2018. Updates in anthracyclinemediated cardiotoxicity. Front.Pharmacol., 9: 1262.

View at Google Scholar

24.Octavia, Y., Tocchetti, C.G., Gabrielson, K.L., Janssens, S., Crijns, H.J. and Moens, A.L. 2012. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies.J. Mol. Cell Cardiol., 52(6): 1213-1225

View at Google Scholar

25.Orabi, M.A., Khalil, H.M., Abouelela, M.E., Zaafar, D., Ahmed, Y.H., Naggar, R.A. and Hamdan, D.I. 2021. Carissa macrocarpa leaves polar fraction ameliorates doxorubicininduced neurotoxicity in rats via downregulating the oxidative stress and inflammatory markers. Pharmaceuticals, 14(12): 1305.

View at Google Scholar

26.Prasanna, P.L., Renu, K. and Gopalakrishnan, A.V. 2020. New molecular and biochemical insights of doxorubicin-induced hepatotoxicity. Life Sci., 250: 117599.

View at Google Scholar

27.Rahimi, B.M., Momeny, M., Babaeikelishomi, R., Mehr, S.E., Tavangar, S.M. and Dehpour, A.R. 2010. The modulatory effect of lithium on doxorubicin- induced cardiotoxicity in rat. Eur. J. Pharmacol., 641(2-3): 193-198.

View at Google Scholar

28.Renu, K., Abilash, V.G., PB T.P. and Arunachalam, S. 2018. Molecular mechanism of doxorubicin-induced cardiomyopathy–An update. Eur. J. Pharmacol.,818: 241- 253.

View at Google Scholar

29.Sandamali, J.A.N., Hewawasam, R.P., Fernando, M.A.C.S.S. and Jayatilaka, K.A.P. W., Madurawe, R. D., Sathananthan, P. P., Ekanayake, U. and Horadugoda, J. 2020. Anthracycline- Induced Cardiotoxicity in Breast Cancer Patients from Southern Sri Lanka: An Echocardiographic Analysis. Biomed. Res. Int., 2020: 1847159.

View at Google Scholar

30.Soliman, A.G., Mahmoud, B., Eldin, Z.E., El-Shahawy, A.A. and Abdel-Gabbar, M. 2023. Optimized synthesis characterization and protective activity of quercetin and quercetin–chitosan nanoformula against cardiotoxicity that was induced in male Wister rats via anticancer agent: doxorubicin. Cancer Nanotechnol., 14(1): 10.

View at Google Scholar

31.Soltani Hekmat, A., Chenari, A., Alipanah, H. and Javanmardi, K. 2021. Protective effect of alamandine on doxorubicininduced nephrotoxicity in rats. BMC Pharmacol Toxicol., 22(1): 1-11.

View at Google Scholar

32.Song, S., Chu, L., Liang, H., Chen, J., Liang, J., Huang, Z. and Chen, X. 2019. Protective effects of dioscin against doxorubicin-induced hepatotoxicity via regulation of Sirt1/ FOXO1/NF-κb signal. Front Pharmacol.,10: 1030.

View at Google Scholar

33.Suarez, J., Herrera, M.D. and Marhuenda, E. 1998. In vitro scavenger and antioxidant properties of hesperidin and neohesperidin dihydrochalcone. Phytomedicine, 5(6): 469- 473.

View at Google Scholar

34.Syahputra, R.A., Harahap, U., Dalimunthe, A., Nasution, M.P. and Satria, D. 2022. The role of flavonoids as a cardioprotective strategy against doxorubicin-induced cardiotoxicity. Molecules, 27(4): 1320.

View at Google Scholar

35.Yu, J., Wang, C., Kong, Q., Wu, X., Lu J.J. and Chen, X. 2018. Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products. Phytomedicine, 40: 125-139.

View at Google Scholar

@International Journal of Fermented Foods | Association with SASNET | Printed by New Delhi Publishers

66745326 - Visitors since April 13, 2019